Endocrine Abstracts

The prevalence of primary hyperparthyroidism (PT) in the general population is 0.15%. The incidence in pregnancy is unknown; however primary hyperparathyroidism during pregnancy poses significant maternal and fetal complications. Complications to the mother include nephrolithiasis, bone disease and muscle weakness. Fetal complications include fetal loss, intrauterine growth retardation, postpartum neonatal tetany and permanent hypoparathyroidism. The symptoms of PT are similar...

Kisspeptin, encoded by the KiSS-1 gene activates the G protein coupled receptor 54 (GPR54). The kisspeptin/GPR54 system plays an essential role regulating reproductive development. The human placenta has a high expression of both the KiSS-1 and GPR54 genes. Plasma kisspeptin levels increase several thousand fold in pregnancy. The physiological role of kisspeptin in pregnancy is not clear. Kisspeptin causes vasoconstriction during in vitro studies and may play a r...